Perchlorate is a naturally occurring and manmade chemical that can affect the functioning of the thyroid gland at sufficiently high doses. In addition to the detrimental effects this toxin can have on thyroid health, in his book Dr. Brownstein also discussed … The following chronic (long-term) health effects can occur at some time after exposure to Potassium Perchlorate and can last for months or years: Cancer Hazard * According to the information presently available to the New Jersey Department of Health and Senior Services, Potassium Perchlorate has not been tested for its ability to cause cancer in animals. by Asha Srinivasan 1 and Thiruvenkatachari Viraraghavan 2,* 1. The Agency found that perchlorate may have an adverse effect on the health of persons and is known to occur in public drinking water systems with a frequency and at levels that present a public health concern. This updates the previous California PHG of 6 ppb perchlorate, which was set in 2004. The study also did not assess potential health effects of exposure. Perchlorate acts pharmacologically as a competitive inhibitor of thyroidal iodide uptake in mammals, but the impacts of perchlorate contamination in aquatic ecosystems and, in particular, the effects on fish are unclear. The California Office of Environmental Health Hazard Assessment (OEHHA) published an updated public health goal (PHG) of 1 part per billion (ppb) for perchlorate in drinking water in February 2015. EPA then worked with the FDA to develop a dose-response model to analyze the effects of perchlorate on thyroid hormone production. Health Effects Assessment for Environmental Perchlorate Contamination: The Dose Response for Inhibition of Thyroidal Radioiodine Uptake in Humans Monte A. Greer,1 Gay Goodman,2 Richard C. Pleus,2 and Susan E. Greer1 1Oregon Health & Science University, Portland, Oregon, USA; 2Intertox, Inc., Seattle, Washington, USA The ammonium salt of the perchlorate ion is manufactured primarily for use … Perchlorate Health Effects. Human Health. The updated PHG is lower because it incorporates new research about the effects of perchlorate on infants. This interference may lead to developmental defects. Perchlorate exposure occurs from ingestion of natural or man-made perchlorate in food or water. For perchlorate in drinking water, as with any other substance, it is the amount of exposure (the dose) that matters in assessing possible adverse effects. Perchlorate Human Health Effects Materials. What are the Human Health Effects of Perchlorate? In 2011, EPA determined that perchlorate meets the Safe Drinking Water Act criteria for regulation as a contaminant. What other studies might be needed? I first learned about perchlorate a number of years ago when reading Dr. David Brownstein's well known book "Iodine, Why You Need It, Why You Can't Live Without It". 1. They are very potent oxidizing agents; exposure may result in hemolysis with methemoglobin formation and secondary DIC. Chlorates are nephrotoxic; acute renal failure may occur. [PMC free article] Greer MA, Goodman G, Pleus RC, Greer SE. 2. In the first and second editions, these constituted Volume 2 of the GDWQ. Iodide is an essential component in two hormones produced by the thyroid. Perchlorate exerts its effects by competing with iodide at the sodium-iodide symporter (NIS), the transport system that transports iodine into the thyroid gland. Faculty of Engineering, University of Regina, Regina, SK, S4S 0A2, Canada. For all of these reasons, this study does not change CDC’s existing recommendations for infant feeding. It is also noted that perchlorate can cross the placenta of guinea pigs, and may possibly produce goiter in the fetus. thus, has been used treat hyperthyroidism since 1950s. Perchlorate is measured in environmental samples primarily by ion chromatography. Int. In “Health Effects Assessment for Environmental Perchlorate Contamination,” by Greer et al. Perchlorate Behavior in a Municipal Lake Following Fireworks Displays [185 KB] Perchlorate salts of potassium and ammonium are the primary oxidants in pyrotechnic mixtures, yet insufficient information is available regarding the relationship between fireworks displays and the environmental occurrence of perchlorate. Health Canada. Perchlorate is an environmental contaminant that blocks iodine/iodide uptake into the thyroid gland (1). 2015. doi: 10.1289/ehp.1409614. Perchlorate in Water Supplies: Sources, Exposures, and Health Effects Craig M. 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